What is the main purpose of random allocation in a clinical trial?
Answer and explanation
Correct answer: C. To spread known and unknown confounders evenly
- Step 1: Allocation by choice would introduce selection bias. Step 2. Random allocation, with concealment, balances prognostic factors by chance, and blinding reduces observer and performance bias. Answer: To spread known and unknown confounders evenly. Why not the others: Patient knowledge of treatment is the opposite of blinding. Cost is not the aim. A control group is still needed.
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