Which statement about metformin and renal function is correct?
Answer and explanation
Correct answer: A. It should be avoided when eGFR is below 30
- Step 1: Metformin is renally excreted and accumulates in renal impairment. Step 2. BNF and NICE guidance advise stopping at an eGFR below 30 and reviewing the dose below 45. Answer: It should be avoided when eGFR is below 30. Why not the others: It is not safe at any level. Doubling would worsen accumulation. It raises rather than lowers the risk of lactic acidosis.
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