A man with alcohol dependence has completed detoxification and wants to prevent relapse. Which drug acts as an opioid antagonist to reduce craving?

Answer and explanation

Correct answer: A. Naltrexone

  1. Step 1: Relapse prevention drugs complement psychosocial support. Step 2. Naltrexone reduces the rewarding effects of alcohol and cravings, and acamprosate is an alternative. Answer: Naltrexone. Why not the others: Disulfiram inhibits aldehyde dehydrogenase to produce an aversive reaction. Chlordiazepoxide is used for detoxification. Thiamine prevents Wernicke encephalopathy.

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A man with alcohol… | UKMLA Applied Knowledge Test (MSRA-style single best answer)