A 24-year-old medical student sustains a needle-stick injury from an HBsAg-positive patient. The student received 3 hepatitis B vaccine doses 5 years ago, and current anti-HBs titer is 180 mIU/mL. What post-exposure management is indicated?

Answer and explanation

Correct answer: C. No active treatment or prophylaxis required

  1. Step 1: An anti-HBs surface antibody titer >= 10 mIU/mL indicates protective immunity against hepatitis B virus infection.
  2. Step 2: Healthcare workers with documented vaccine response (anti-HBs >= 10 mIU/mL) do not require post-exposure prophylaxis with HBIG or booster vaccine doses following exposure to an HBsAg-positive source.
Answer
No active treatment or prophylaxis required.
Why not the others: 'Administer Hepatitis B immune globulin (HBIG) only' is indicated for non-responders or unvaccinated individuals; 'Administer full 3-dose hepatitis B vaccine series' is required for previously unvaccinated personnel; 'Initiate oral tenofovir' is not indicated for HBV post-exposure prophylaxis in immune individuals.

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