During which phase of cellular mitosis do sister chromatids separate at their centromeres and migrate toward opposite spindle poles?
Answer and explanation
Correct answer: B. Anaphase
- Step 1: Mitotic phases in order: Prophase -> Metaphase -> Anaphase -> Telophase.
- Step 2: In Anaphase, cohesin proteins are cleaved by separase, permitting spindle fibers to pull identical sister chromatids toward opposite poles of the dividing cell.
Answer
Anaphase.
Why not the others: 'Prophase' involves chromatin condensation and nuclear envelope breakdown; 'Metaphase' aligns chromosomes along the equatorial metaphase plate; 'Telophase' reforms nuclear membranes around daughter nuclei.
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