Answer and explanation

Correct answer: A. into

  1. Step 1: 'Come into effect' is the fixed expression for rules starting to apply.
Answer
into.
Why not the others: "in" is wrong because 'come in effect' is not the fixed expression. "on" is wrong because 'come on effect' is not an expression. "at" is wrong because 'come at effect' is not an expression.

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