Where does the Tricarboxylic Acid (TCA or Krebs) cycle take place inside eukaryotic cells?
Answer and explanation
Correct answer: D. Mitochondrial matrix
- Step 1: Pyruvate is transported into mitochondria and converted to acetyl-CoA by pyruvate dehydrogenase. Step 2. Acetyl-CoA is completely oxidized in the Krebs cycle located in the soluble mitochondrial matrix. Answer: Mitochondrial matrix. Why not the others: Inner mitochondrial membrane contains respiratory complexes I-IV and ATP synthase; intermembrane space accumulates pumped protons; cytoplasm hosts glycolysis.
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