According to the modified Duke criteria, which clinical finding constitutes a major criterion for infective endocarditis?
Answer and explanation
Correct answer: C. Intracardiac vegetation on echocardiogram
- Step 1: The modified Duke criteria categorize manifestations of infective endocarditis into major and minor criteria.
- Step 2: Major criteria include persistently positive blood cultures for typical organisms and evidence of endocardial involvement such as an oscillating intracardiac vegetation or new valvular regurgitation on echocardiography.
Answer
Intracardiac vegetation on echocardiogram.
Why not the others: Fever is categorized as a minor criterion under predisposing conditions and pyrexia. Osler nodes represent immunologic phenomena classified as minor criteria. Roth spots represent retinal hemorrhages classified as minor immunologic criteria.
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