Under the KDIGO guidelines, which serum creatinine change within 48 hours defines Stage 1 Acute Kidney Injury (AKI)?
Answer and explanation
Correct answer: B. Increase by 0.3 mg/dL or greater
- Step 1: The Kidney Disease: Improving Global Outcomes consensus framework defines acute kidney injury using serum creatinine and urine output parameters.
- Step 2: Stage 1 AKI is defined by an absolute increase in serum creatinine of 0.3 mg/dL or greater within 48 hours, or a 1.5 to 1.9-fold increase from baseline within 7 days.
Answer
Increase by 0.3 mg/dL or greater.
Why not the others: An increase of 2.0 to 2.9 times baseline defines Stage 2 AKI. An increase to 4.0 mg/dL or a 3-fold rise from baseline defines Stage 3 AKI. A decrease in serum creatinine represents improving renal function rather than acute kidney injury.
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