A pregnant patient at 32 weeks gestation is diagnosed with chronic hypertension. Which antihypertensive drug class is strictly contraindicated due to fetotoxicity and renal dysgenesis?
Answer and explanation
Correct answer: A. Angiotensin-converting enzyme inhibitors
Answer: Angiotensin-converting enzyme inhibitors.
Why not the others: ACE inhibitors and ARBs cause fetal renal dysgenesis, oligohydramnios, and fetal demise; Centrally acting alpha-2 agonists such as methyldopa have an established safety profile in pregnancy; Labetalol is widely used for gestational hypertension; Hydralazine is safe in pregnancy.
Why not the others: ACE inhibitors and ARBs cause fetal renal dysgenesis, oligohydramnios, and fetal demise; Centrally acting alpha-2 agonists such as methyldopa have an established safety profile in pregnancy; Labetalol is widely used for gestational hypertension; Hydralazine is safe in pregnancy.
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