A patient with refractory schizophrenia is treated with clozapine. Which life-threatening hematologic adverse effect requires mandatory regular absolute neutrophil count monitoring?
Answer and explanation
Correct answer: B. Agranulocytosis
Answer: Agranulocytosis.
Why not the others: Clozapine induces severe neutropenia and agranulocytosis in 1 to 2 percent of patients; Polycythemia vera is a myeloproliferative neoplasm involving red cell excess; Clozapine does not characteristically cause isolated immune thrombocytopenia or Coombs-positive hemolytic anemia.
Why not the others: Clozapine induces severe neutropenia and agranulocytosis in 1 to 2 percent of patients; Polycythemia vera is a myeloproliferative neoplasm involving red cell excess; Clozapine does not characteristically cause isolated immune thrombocytopenia or Coombs-positive hemolytic anemia.
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