Which lipid-lowering medication class requires baseline and periodic assessment of liver enzymes and monitoring for muscle pain due to rhabdomyolysis risk?
Answer and explanation
Correct answer: D. HMG-CoA reductase inhibitors
Answer: HMG-CoA reductase inhibitors.
Why not the others: Statins (HMG-CoA reductase inhibitors) carry well-documented risks of myopathy, elevated creatine kinase, and rhabdomyolysis; Bile acid sequestrants act locally in the intestinal lumen; Ezetimibe has lower myopathy incidence unless combined with statins; Omega-3 esters primarily lower triglycerides without causing myositis.
Why not the others: Statins (HMG-CoA reductase inhibitors) carry well-documented risks of myopathy, elevated creatine kinase, and rhabdomyolysis; Bile acid sequestrants act locally in the intestinal lumen; Ezetimibe has lower myopathy incidence unless combined with statins; Omega-3 esters primarily lower triglycerides without causing myositis.
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