Which consensus promoter sequence, situated roughly 25 to 30 base pairs upstream of the transcription start site, binds TFIID in eukaryotic protein-coding genes?
Answer and explanation
Correct answer: D. The TATA box (Goldberg-Hogness box)
The TATA box (consensus sequence 5'-TATAAA-3') is located approximately 25-30 base pairs upstream of the transcription start site in eukaryotic core promoters and is recognized by the TATA-binding protein (TBP) subunit of TFIID. The Pribnow box and Shine-Dalgarno sequences are bacterial, while the Kozak sequence assists eukaryotic ribosomal initiation in mRNA translation.
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