Which type of mutation results from a single base substitution that converts a codon specifying an amino acid into a premature stop codon?
Answer and explanation
Correct answer: D. Nonsense mutation
A nonsense mutation is a point mutation in which a nucleotide substitution alters a codon from one that codes for an amino acid into one of the three translation termination codons (UAA, UAG, or UGA), resulting in truncated, usually non-functional polypeptide products. Missense mutations change an amino acid, silent mutations do not alter the amino acid, and insertions add bases.
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