During the intrinsic pathway of apoptosis, which mitochondrial protein is released into the cytosol to bind Apaf-1 and form the apoptosome complex?
Answer and explanation
Correct answer: C. Cytochrome c
In response to intrinsic pro-apoptotic stimuli, pro-apoptotic proteins Bax and Bak form pores in the outer mitochondrial membrane, releasing cytochrome c from the intermembrane space into the cytosol. Cytosolic cytochrome c binds apoptotic protease activating factor-1 (Apaf-1) in the presence of dATP, assembling the heptameric apoptosome which cleaves and activates procaspase-9.
Practise more Cellular Biology, Molecular Genetics, and General Genetics.
Free questions with an explanation for every one, and full timed Toelatingsexamen Arts & Tandarts België (Medical & Dental Entrance Exam) mock tests.
More Cellular Biology, Molecular Genetics, and General Genetics questions
- What is the primary role of cholesterol in animal cell plasma membranes at low physiological temperatures?
- Which stoichiometry describes the transport cycle of the standard sodium-potassium pump (Na+/K+-ATPase)?
- By which transport mechanism does D-glucose cross the apical membrane of intestinal enterocytes against its concentration gradient?
- Which cellular organelle is primarily responsible for the post-translational mannose-6-phosphate tagging that targets acid hydrolases to lys…
- In eukaryotic cellular respiration, what is the immediate source of energy that directly drives ATP synthesis by the mitochondrial ATP synth…
- During which phase of mitotic cell division do sister chromatids synchronously separate and move toward opposite spindle poles?