A medical screening test for a rare disease has a sensitivity of 95% and a specificity of 90%. In a population where the disease prevalence is 1%, what is the probability that an individual who tests positive actually has the disease (positive predictive value)?

Answer and explanation

Correct answer: A. 8.8% (approximately 9%)

In a sample of 10,000 people: 1% prevalence means 100 have the disease and 9,900 are healthy. Of the 100 diseased, 95% test positive = 95 true positives. Of the 9,900 healthy, 10% test false positive = 990 false positives. Total positive tests = 95 + 990 = 1,085. Positive predictive value (PPV) = true positives / total positives = 95 / 1,085 ≈ 0.0876 (or ~8.8%).

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