Furosemide produces its diuretic effect by blocking which transporter?
Answer and explanation
Correct answer: C. The Na-K-2Cl cotransporter in the thick ascending limb
- Step 1: Loop diuretics bind the NKCC2 cotransporter of the thick ascending limb. Step 2. This stops the generation of the medullary gradient and gives a large diuresis. Answer: the Na-K-2Cl cotransporter. Why not the others: the Na-Cl cotransporter is the thiazide target, the epithelial sodium channel is blocked by amiloride, and SGLT2 inhibitors act in the proximal tubule.
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