A farmer arrives with salivation, lacrimation, diarrhea, miosis and bradycardia after spraying pesticide. Which pair of drugs is the appropriate treatment?
Answer and explanation
Correct answer: B. Atropine and pralidoxime
- Step 1: Organophosphates inhibit acetylcholinesterase, so acetylcholine accumulates. Step 2. Atropine blocks the muscarinic effects, and pralidoxime reactivates the enzyme if given early. Answer: atropine and pralidoxime. Why not the others: physostigmine and neostigmine would worsen the toxicity, and the other pairs treat opioid or benzodiazepine toxicity or are not antidotes.
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