A 55-year-old alcoholic man has cirrhosis. Which finding on liver histology is typical of alcoholic hepatitis?
Answer and explanation
Correct answer: A. Mallory-Denk bodies and neutrophilic infiltration
- Step 1: Alcoholic hepatitis shows ballooned hepatocytes with Mallory-Denk bodies and neutrophils. Step 2. AST is usually higher than ALT, at a ratio above 2. Answer: Mallory-Denk bodies with neutrophils. Why not the others: Councilman bodies are seen in viral hepatitis, the PAS-positive globules in alpha-1 antitrypsin deficiency and plasma cells in autoimmune hepatitis.
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