Which enzyme catalyzes the rate-limiting step of glycolysis?
Answer and explanation
Correct answer: D. Phosphofructokinase-1
- Step 1: Phosphofructokinase-1 converts fructose-6-phosphate to fructose-1,6-bisphosphate and is the main control point. Step 2. It is inhibited by ATP and citrate and activated by AMP and fructose-2,6-bisphosphate. Answer: phosphofructokinase-1. Why not the others: hexokinase and pyruvate kinase are regulated steps, but PFK-1 is the committed, rate-limiting one.
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