Which carboxylic acid derivative exhibits the greatest reactivity toward nucleophilic acyl substitution?
Answer and explanation
Correct answer: B. Acyl chlorides
Reactivity order is: Acyl chloride > Acid anhydride > Ester > Amide. Chloride is a very weak base and excellent leaving group, and the carbonyl carbon is strongly electron-deficient, making acyl chlorides the most reactive derivatives.
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