Which allosteric enzyme catalyzes the committed, rate-limiting step of glycolysis in human cells?
Answer and explanation
Correct answer: A. Phosphofructokinase-1
PFK-1 catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate using ATP. It is allosterically inhibited by high ATP and citrate, and strongly activated by AMP and fructose-2,6-bisphosphate.
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