What is the primary metabolic fate of acetyl-CoA in the mitochondrial matrix during energy production?
Answer and explanation
Correct answer: D. Condensation with oxaloacetate to form citrate in the citric acid cycle
Acetyl-CoA condenses with four-carbon oxaloacetate catalyzed by citrate synthase to form six-carbon citrate, initiating the citric acid (Krebs) cycle. Humans cannot convert acetyl-CoA net into glucose (PDH reaction is irreversible).
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