Which intravenous anesthetic agent is classic for causing acute malignant hyperthermia in genetically susceptible individuals with ryanodine receptor (RYR1) gene mutations?
Answer and explanation
Correct answer: B. Succinylcholine (and volatile halogenated inhalational anesthetics)
- Step 1: Malignant hyperthermia is triggered by depolarizing neuromuscular blockers (succinylcholine) and volatile anesthetics (halothane, isoflurane, sevoflurane).
- Step 2: Uncontrolled calcium release from the sarcoplasmic reticulum leads to hypermetabolism, sustained muscle rigidity, hyperthermia, and rhabdomyolysis.
- Step 3: Dantrolene sodium is the specific intravenous antidote.
Answer
Succinylcholine (and volatile halogenated inhalational anesthetics).
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