A 40-year-old male presents with recurrent peptic ulcer disease and recurrent calcium nephrolithiasis. Serum calcium is 11.2 mg/dL with inappropriately elevated parathyroid hormone (PTH). Multiple Endocrine Neoplasia type 1 (MEN1) is suspected. What three primary organs are affected in MEN1?
Answer and explanation
Correct answer: B. Parathyroid glands, anterior pituitary gland, and endocrine pancreas
- Step 1: MEN1 (Wermer syndrome) is an autosomal dominant condition caused by mutations in the menin tumor suppressor gene on chromosome 11q13.
- Step 2: The classic organs involved are the '3 Ps': Parathyroid (hyperplasia/adenoma, 95%), Pancreas (gastrinoma, insulinoma, 60%), and Pituitary (prolactinoma, 30%).
- Step 3: MEN2 involves medullary thyroid carcinoma and pheochromocytoma.
Answer
Parathyroid glands, anterior pituitary gland, and endocrine pancreas.
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