A 55-year-old postmenopausal female presents with painless light vaginal bleeding for 2 weeks. She has been in menopause for 4 years and takes no hormone replacement therapy. What is the mandatory next diagnostic step?

Answer and explanation

Correct answer: D. Endometrial biopsy to rule out endometrial carcinoma

  1. Step 1: Postmenopausal bleeding is endometrial cancer until proven otherwise (approximately 10% of cases are malignant).
  2. Step 2: Transvaginal ultrasound (evaluating endometrial thickness, where > 4 mm is abnormal) and office endometrial biopsy are mandatory initial steps.
  3. Step 3: Endometrial tissue sampling provides histological diagnosis and directs oncological staging.
Answer
Endometrial biopsy to rule out endometrial carcinoma.

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