ペン___書きます。 (I write with a pen.)

Answer and explanation

Correct answer: C. で

で marks the tool or means used for an action.
Answer: で.
Why not the others: を: を would mark the pen as the thing written. が: が marks a subject. に: に marks a destination.

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ペン 書きます。 (I write with a… | JLPT Practice (N5 and N4) - Japan