Which investigation best confirms Hirschsprung disease?

Answer and explanation

Correct answer: D. Rectal suction biopsy

  1. Step 1: The test that best confirms Hirschsprung disease is: rectal suction biopsy.
Answer
Rectal suction biopsy.
Why not the others: 'Plain abdominal radiograph': it shows dilated bowel but cannot confirm the diagnosis. 'Sweat chloride test': it screens for cystic fibrosis. 'Barium meal': it examines the upper gut.

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