Which drug class improves mortality in heart failure with reduced ejection fraction?
Answer and explanation
Correct answer: B. ACE inhibitor with an evidence-based beta-blocker
- Step 1: Neurohormonal blockade improves survival in reduced ejection fraction.
- Step 2: Diuretics are added for congestion.
Answer
ACE inhibitor with an evidence-based beta-blocker.
Why not the others: 'Loop diuretics alone' relieve symptoms but do not improve survival; 'Digoxin alone' improves symptoms but not mortality; 'Calcium channel blocker verapamil' can worsen reduced ejection fraction.
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