Answer and explanation

Correct answer: B. Estimated GFR below 30 mL/min

  1. Step 1: Metformin accumulates in renal failure.
  2. Step 2: This raises the risk of lactic acidosis.
Answer
Estimated GFR below 30 mL/min.
Why not the others: 'HbA1c of 7.5%' is a reason to adjust therapy, not stop it; 'BMI of 31' is not a contraindication; 'Mild peripheral neuropathy' is not a contraindication.

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