A 60-year-old man has resting tremor, bradykinesia and rigidity. Which pathologic finding is expected?
Answer and explanation
Correct answer: D. Loss of dopaminergic neurons in the substantia nigra with Lewy bodies
- Step 1: Parkinson disease features nigral cell loss and alpha-synuclein inclusions. Answer: Loss of dopaminergic neurons in the substantia nigra with Lewy bodies. Why not the others: Tangles suggest Alzheimer, caudate atrophy Huntington and demyelination multiple sclerosis.
Practise more Pathology.
Free questions with an explanation for every one, and full timed USMLE Step 1 mock tests.
More Pathology questions
- A 40-year-old man with a long history of reflux has a distal esophagus lined with columnar epithelium and goblet cells. What is the complica…
- A 55-year-old woman has a mole that has changed in color and size. Biopsy shows atypical melanocytes invading the dermis. Which feature best…
- An 8-year-old boy has bowed legs, widened wrists and a rachitic rosary. Which vitamin deficiency is most likely?
- A 25-year-old man has painless cervical lymphadenopathy and Reed-Sternberg cells with owl-eye nuclei on biopsy. What is the diagnosis?
- A 60-year-old man has a swollen, red first metatarsophalangeal joint. Joint fluid shows negatively birefringent needle-shaped crystals. What…
- A 58-year-old man has crushing chest pain for 2 hours. ECG shows ST elevation in leads II, III and aVF. Which coronary artery is most likely…