A 55-year-old man has hematuria and a renal mass. Biopsy shows clear cells with abundant glycogen. Which genetic abnormality is typical?
Answer and explanation
Correct answer: D. Loss of VHL gene on chromosome 3
- Step 1: Clear cell renal carcinoma is associated with VHL loss. Answer: Loss of VHL gene on chromosome 3. Why not the others: WT1 is linked to Wilms tumor, RB1 to retinoblastoma and APC to colon polyposis.
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