Consider the following statements regarding 'mRNA Vaccines':
1. They introduce weakened or inactivated viral particles directly into host tissue.
2. The mRNA instructions degrade rapidly within host cells after protein synthesis.
Which of the statements given above is/are correct?
Answer and explanation
Correct answer: D. 2 only
- Step 1: Statement 1 is incorrect: Unlike conventional vaccines that use attenuated or inactivated viral pathogens, mRNA vaccines deliver lipid nanoparticle-encapsulated synthetic messenger RNA encoding a harmless target antigen (such as a viral surface spike protein).
- Step 2: Statement 2 is correct: Once translated by host cellular ribosomes into the target antigen, the exogenous mRNA strand is quickly hydrolyzed and degraded by cellular ribonucleases without altering host genomic DNA.
Answer
2 only.
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