Which oral hypoglycemic agent from the biguanide class is first-line pharmacotherapy for type 2 diabetes mellitus in patients with preserved renal function?
Answer and explanation
Correct answer: A. Metformin
- Step 1: Biguanides are oral antihyperglycemic agents that decrease hepatic gluconeogenesis and increase peripheral glucose uptake.
- Step 2: International clinical guidelines universally establish Metformin as the first-line oral pharmacological therapy for type 2 diabetes mellitus in patients with adequate renal function.
Answer
Metformin.
Why not the others: Glipizide is a sulfonylurea insulin secretagogue, Sitagliptin is a DPP-4 inhibitor, and Pioglitazone is a thiazolidinedione PPAR-gamma agonist.
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