Which screening test is universally recommended for early secondary prevention and detection of colorectal cancer in asymptomatic adults beginning at age 45-50?

Answer and explanation

Correct answer: B. Colonoscopy every 10 years or annual FIT testing

  1. Step 1: Population-based secondary prevention of colorectal cancer in average-risk, asymptomatic adults aims to detect and remove precancerous polyps and identify localized malignancy.
  2. Step 2: Clinical screening guidelines universally endorse screening colonoscopy every 10 years or annual fecal immunochemical testing (FIT) beginning at age 45 to 50.
Answer
Colonoscopy every 10 years or annual FIT testing.
Why not the others: Abdominal ultrasound cannot visualize colonic mucosa or small adenomatous polyps, serum CEA quantification is used for monitoring recurrent disease rather than screening, and barium enema has lower sensitivity and lacks biopsy capability.

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