Which drug class has been shown to reduce mortality in heart failure with reduced ejection fraction?
Answer and explanation
Correct answer: B. Evidence-based beta-blockers such
- Step 1: In HFrEF, neurohormonal blockade improves survival. Step 2. Beta-blockers, ACE inhibitors or ARNI, mineralocorticoid antagonists and SGLT2 inhibitors all reduce mortality. Answer: evidence-based beta-blockers. Why not the others: Diuretics relieve congestion without a survival benefit; verapamil and class I antiarrhythmics can worsen outcome.
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