A non-protein chemical component that is tightly and permanently bound to the apoenzyme to constitute a functional holoenzyme is designated as a:
Answer and explanation
Correct answer: A. Prosthetic group
- Step 1: Conjugated enzymes consist of a protein moiety (apoenzyme) and a non-protein cofactor.
- Step 2: When the non-protein cofactor is organic and transiently/loosely associated (e.g., , ), it is termed a coenzyme.
- Step 3: When the organic cofactor is covalently or tightly bound to the protein framework (such as heme in catalase and peroxidase, or biotin), it is defined as a prosthetic group.
Answer
Prosthetic group.
Why not the others: Coenzyme refers to loosely bound, easily dissociable organic cofactors (often vitamin derivatives); Metal activator ion refers to inorganic cations like or ; Allosteric modulator binds reversibly to non-catalytic sites to regulate activity.
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