What type of bond stabilizes the secondary structure (-helix and -pleated sheet) of globular proteins?
Answer and explanation
Correct answer: A. Hydrogen bonds between peptide backbone amide (N-H) and carbonyl (C=O) groups
- Step 1: Secondary protein structure refers to local spatial folding of the polypeptide backbone.
- Step 2: Linus Pauling established that both -helices and -sheets are stabilized by regular hydrogen bonds.
- Step 3: These bonds form exclusively between the carbonyl oxygen () of one peptide bond and the amino hydrogen () of another along the backbone.
Answer
Hydrogen bonds between peptide backbone amide (N-H) and carbonyl (C=O) groups.
Why not the others: Covalent disulfide bonds stabilize tertiary and quaternary structures; Hydrophobic interactions drive tertiary core collapse; Ionic salt bridges stabilize tertiary side-chain folding.
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