Which level of protein structural organization is NOT destroyed when a native globular protein is thermally denatured?
Answer and explanation
Correct answer: C. Primary structure
- Step 1: Protein denaturation is caused by heat, extreme pH, or organic solvents that disrupt non-covalent interactions.
- Step 2: Hydrogen bonds, hydrophobic interactions, and ionic bridges unfold, disrupting secondary (-helices, -sheets), tertiary, and quaternary conformations.
- Step 3: However, the strong covalent peptide bonds linking adjacent amino acids along the polypeptide backbone remain intact; thus, the primary structure is preserved.
Answer
Primary structure.
Why not the others: Secondary structure unfolds as backbone hydrogen bonds break; Tertiary structure collapses as non-covalent core interactions are abolished; Quaternary structure dissociates into individual uncoordinated subunits.
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