Which anatomical structure provides nutritional and physical support to developing spermatogenic germ cells, forms the blood-testis barrier, and secretes androgen-binding protein (ABP)?
Answer and explanation
Correct answer: C. Sertoli cells
- Step 1: Sertoli cells are elongated, pyramidal epithelial cells spanning the entire seminiferous epithelium.
- Step 2: Adjacent Sertoli cells form tight junctions that create the blood-testis barrier, preventing autoimmune destruction of haploid germ cells.
- Step 3: Under follicle-stimulating hormone (FSH) stimulation, they secrete androgen-binding protein (ABP) to concentrate testosterone within the tubular lumen, as well as inhibin to regulate pituitary FSH release.
Answer
Sertoli cells (sustentacular cells).
Why not the others: Leydig cells secrete testosterone in the interstitial stroma; Cowper's glands secrete alkaline pre-ejaculatory lubricating mucus; Epididymal cells store and mature spermatozoa.
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