USMLE Step 1 · USMLE Step 1: Medical Sciences

General Pharmacology and Autonomic Pharmacodynamics

6 practice questions, each with the answer and an explanation.

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A competitive antagonist shifts the agonist dose-response curve in which direction without altering the maximal efficacy ( $E_{m a x}$ )?
A 65-year-old man with benign prostatic hyperplasia and chronic open-angle glaucoma receives an over-the-counter cold medication containing pseudoephedrine and diphenhydramine. He develops acute urina…
A drug follows first-order elimination kinetics. If its elimination half-life ( $t_{1/2}$ ) is $4 hours$ , what percentage of the initial drug concentration remains in the body after…
A 32-year-old farmer is rushed to the emergency department with excessive salivation, lacrimation, urination, defecation, bronchospasm, and pinpoint pupils (miosis) after spraying his crops. Which ant…
A 58-year-old woman undergoing chemotherapy with cyclophosphamide is prescribed Mesna to prevent which dose-limiting adverse effect?
A clinical trial evaluates a new monoclonal antibody. The volume of distribution ( $V_{d}$ ) is calculated to be $4.5 L$ in a $70 kg$ adult subject. This $V_{d}$ value suggests that the drug i…

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