PLAB 1 (GMC, international medical graduates) · Medicine and specialties

Neurology, gastroenterology and endocrine

8 practice questions, each with the answer and an explanation.

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Random questions from this topic, one at a time. You see the answer and the explanation straight after each one.

All 8 questions

  1. A 25-year-old woman has a severe unilateral throbbing headache with nausea and photophobia that lasts 24 hours. She has had similar attacks monthly. Which acute treatment is most appropriate?
  2. A 70-year-old man has a resting tremor, rigidity and bradykinesia. Which drug is first-line for his motor symptoms if they affect his quality of life?
  3. A 22-year-old woman has episodes of blank staring lasting 10 seconds many times a day, with no postictal confusion. EEG shows 3 Hz spike and wave. Which drug is first-line?
  4. A 30-year-old man has ascending weakness and areflexia two weeks after a diarrhoeal illness. His forced vital capacity is falling. What is the most appropriate treatment?
  5. A 52-year-old man with alcohol dependence is admitted confused, ataxic and with abnormal eye movements. His glucose is 3.0 mmol/L. What should be given first?
  6. A 28-year-old woman has bloody diarrhoea, urgency and abdominal pain for 6 weeks. Colonoscopy shows continuous inflammation from the rectum. What is the likely diagnosis?
  7. A 35-year-old woman has fatigue, iron deficiency and positive anti-tissue transglutaminase antibodies while on a normal diet. What is the next step?
  8. A 65-year-old man has eGFR of 28 mL/min and urine ACR of 80 mg/mmol, and he does not have diabetes. Which action is in line with NICE guidance on chronic kidney disease?

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