A man is found after a long lie with dark urine, a creatine kinase of 40 000 U/L and a potassium of 6.8 mmol/L. What is the most important initial treatment?

Answer and explanation

Correct answer: A. Large-volume intravenous fluid, cardiac monitoring and treatment of the hyperkalaemia

  1. Step 1: Muscle breakdown releases myoglobin and potassium, risking acute kidney injury and arrhythmia. Step 2. Early large-volume IV fluid maintains urine output to clear myoglobin, and hyperkalaemia is treated urgently. Answer: Large-volume intravenous fluid, cardiac monitoring and treatment of the hyperkalaemia. Why not the others: Restricting fluid worsens kidney injury. Diuretics alone do not replace volume. Potassium supplements are dangerous with a level of 6.8.

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