Which clinical condition is caused by a severe dietary deficiency of Vitamin B1 (thiamine)?
Answer and explanation
Correct answer: B. Beriberi
- Step 1: Thiamine pyrophosphate is a key coenzyme for pyruvate dehydrogenase in aerobic carbohydrate metabolism. Step 2. Thiamine deficiency impairs nervous and cardiac energy generation, manifesting as dry or wet beriberi. Answer: Beriberi. Why not the others: Pellagra is niacin deficiency; pernicious anemia is autoimmune intrinsic factor loss preventing B12 absorption; goiter is iodine deficiency.
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