Which structural class of antibiotics includes Streptomycin and Gentamicin that inhibit bacterial protein synthesis by binding to 30S ribosomal subunits?
Answer and explanation
Correct answer: C. Aminoglycosides
- Step 1: Streptomycin and gentamicin are polycationic aminoglycoside antibiotics. Step 2. They bind irreversibly to the bacterial 30S ribosomal subunit, causing codon misreading and premature translation termination. Answer: Aminoglycosides. Why not the others: Macrolides (azithromycin) bind to the 50S subunit; Beta-lactams inhibit cell wall synthesis; Fluoroquinolones inhibit DNA gyrase.
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