What is the standard four-drug regimen administered during the 2-month initial intensive phase of treatment for drug-susceptible pulmonary tuberculosis?
Answer and explanation
Correct answer: B. Rifampin, isoniazid, pyrazinamide, ethambutol
- Step 1: The World Health Organization standard treatment protocol for active drug-susceptible Mycobacterium tuberculosis consists of an initial intensive phase followed by a continuation phase.
- Step 2: The intensive phase consists of 2 months of four first-line antimycobacterial agents: Rifampin, Isoniazid, Pyrazinamide, and Ethambutol (RIPE).
Answer
Rifampin, isoniazid, pyrazinamide, ethambutol.
Why not the others: Fluoroquinolones and macrolides are used for atypical mycobacteria or multidrug-resistant tuberculosis regimens. Dapsone and clofazimine are first-line agents for leprosy (Mycobacterium leprae). Bedaquiline and linezolid are reserved for multidrug-resistant and extensively drug-resistant tuberculosis.
Practise more Clinical Medicine, Emergency Care and Therapeutics.
Free questions with an explanation for every one, and full timed DHA Dubai mock tests.
More Clinical Medicine, Emergency Care and Therapeutics questions
- A 62-year-old male presents with severe crushing retrosternal chest pain. ECG confirms acute ST-elevation myocardial infarction (STEMI). Acc…
- A 45-year-old female presents to the emergency department in septic shock with a mean arterial pressure (MAP) of 52 mmHg despite receiving 3…
- A 28-year-old male with severe acute asthma exacerbation develops acute respiratory distress, tracheal deviation to the right, and absent br…
- A 54-year-old chronic kidney disease patient presents with severe muscle weakness. The serum potassium is 7.2 mEq/L, and ECG shows tall peak…
- A 4-year-old child weighing 18 kg is admitted for dehydration. Using the standard Holliday-Segar formula, what is the calculated 24-hour mai…
- A 36-year-old woman is evaluated for profound fatigue and pallor. Complete blood count shows microcytic hypochromic anemia. Which laboratory…