In evaluating suspected multiple myeloma, which clinical feature is NOT part of the classic CRAB diagnostic criteria?
Answer and explanation
Correct answer: A. Cholestatic liver failure
- Step 1: Multiple myeloma is characterized by neoplastic proliferation of plasma cells in the bone marrow and end-organ tissue damage.
- Step 2: The diagnostic CRAB criteria comprise Hypercalcemia, Renal insufficiency, Anemia, and Bone lytic lesions; cholestatic liver failure is not an element of this acronym.
Answer
Cholestatic liver failure.
Why not the others: Hypercalcemia is a classic CRAB criterion resulting from osteoclast activation. Renal impairment is a cardinal CRAB criterion caused by light chain cast nephropathy. Lytic bone lesions are a fundamental CRAB criterion visible on skeletal imaging.
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