According to the Rotterdam consensus criteria, how many of the three features are required to confirm Polycystic Ovary Syndrome (PCOS)?

Answer and explanation

Correct answer: C. At least two of the three features

  1. Step 1: The three diagnostic criteria under the Rotterdam consensus are oligo- or anovulation, clinical and/or biochemical signs of hyperandrogenism, and polycystic ovaries on ultrasonography.
  2. Step 2: The diagnosis of PCOS requires the presence of at least two of these three features, after excluding other etiologies such as congenital adrenal hyperplasia and hyperprolactinemia.
Answer
At least two of the three features.
Why not the others: Requiring all three features is overly restrictive because many women with ovulatory dysfunction and hyperandrogenism lack classic polycystic ovarian morphology. Polycystic ovarian morphology alone is non-specific and is observed in up to 25% of healthy normal ovulatory women. Hyperandrogenism alone does not establish PCOS without ovulatory dysfunction or polycystic morphology.

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