Which primary neurotransmitter is released by postganglionic sympathetic neurons onto vascular smooth muscle to mediate vasoconstriction?

Answer and explanation

Correct answer: D. Norepinephrine (noradrenaline)

Most postganglionic sympathetic neurons release norepinephrine, which binds to alpha-1 adrenergic receptors on vascular smooth muscle to stimulate contraction (vasoconstriction). Parasympathetic postganglionic neurons and sympathetic preganglionic neurons release acetylcholine.

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