How do cytotoxic CD8+ T lymphocytes recognize foreign antigens on the surface of target cells?
Answer and explanation
Correct answer: C. Bound to Class I MHC molecules expressed on virtually all nucleated cells
Cytotoxic T cells express CD8 coreceptors that bind to the invariant alpha-3 domain of MHC Class I molecules. MHC Class I presents endogenous peptides (such as viral or tumor proteins) synthesized inside nucleated cells to CD8+ T cells, triggering targeted cell destruction via perforin and granzymes.
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